This article is reviewed, corrected, and approved by: Dr. Joshua Collins M.D. | MRCP। FRCP

It is a medication that can be used for several purposes. It contains a substance called Naltrexone but in lower amounts than usual. Here's an overview of both naltrexone and its uses, including LDN.

Naltrexone is primarily known as an opioid receptor antagonist. It blocks the effects caused by opioids, which include pain relief and feelings of happiness. It blocks the brain's opioid receptors from being activated by attaching them.

It is often used at standard doses (usually 50 mg) to help individuals with opioid or alcohol dependence by reducing the rewarding effects of these substances, thereby aiding in addiction treatment.

Low Dose Naltrexone (LDN)

LDN refers to the administration of naltrexone at significantly lower levels than the standard dosage used for addiction therapy. LDN doses generally range from 1.5 mg to 4.5 mg. At these lower doses, naltrexone exhibits a different pharmacological effect, modulating the immune system and influencing endorphin levels in the body.

It's important to note that LDN usage for various conditions is considered off-label, meaning that it's not officially approved by regulatory agencies for these uses.

The Benefits of Naltrexone (LDN)

There are some advantages of using naltrexone, here are

  • A Versatile Treatment: While more research is needed, LDN has shown promise in various conditions
  • Autoimmune Disorders: There some researchers have found that this medication also works for other auto-immune diseases.
  • Chronic Pain: Researchers are studying LDN's potential benefits in patients who have fibromyalgia (chronic pain) and chronic fatigue syndrome.
  • Depression and Mood Disorders: LDN's interaction with endorphins makes it a subject of interest in treating mood-related disorders.
  • Cancer: Some studies are investigating LDN's role as an adjuvant therapy for certain cancers.

Uses of Naltrexone (LDN)

More research is needed to fully understand the effectiveness of LDN and its mechanisms of action. Despite its potential benefits, LDN has gained attention for a wide range of medical conditions. Some potential uses of LDN include:

Autoimmune Disorders

LDN is sometimes used as a treatment option for certain conditions, such as

  1. Systemic lupus erythematosus (SLE)
  2. RA is widely known as Rheumatoid arthritis.
  3. Crohn's disease (a type of chronic inflammatory bowel disease)
  4. Multiple sclerosis (MS)

It's believed to modulate the immune response and reduce inflammation.

Chronic Pain

LDN has been explored as a possible adjunctive treatment for chronic pain conditions, such as fibromyalgia, by influencing the body's pain pathways and possibly enhancing natural pain-relieving mechanisms.

Inflammatory Conditions

LDN's immune-modulating properties have led to its investigation in conditions like Hashimoto's thyroiditis and ulcerative colitis.

Neurological Disorders

Some research suggests that LDN might have potential benefits for neurodegenerative disorders like Parkinson's disease, although further studies are needed to establish its efficacy.

Mood Disorders

There is limited research exploring the use of LDN for mood disorders such as depression and anxiety, possibly due to its interaction with endorphins and neurochemical pathways.


LDN has been investigated in cancer treatment as a potential adjuvant therapy due to its effects on the immune system. However, evidence in this area is preliminary and ongoing.

Naltrexone vs Naloxone

Here are the differences between naltrexone and naloxone





Opioid antagonist

Opioid antagonist

Mechanism of Action

Blocks opioid and endorphin receptors in the body

Reverses opioid overdose effects by displacing opioids from receptors

Approved Uses

Opioid use disorder, alcohol use disorder

Emergency treatment of opioid overdoses

Dosage Forms

Oral tablets, intramuscular injection

Injectable form, Nasal spray (intramuscular or intranasal)

Duration of Action

Longer-lasting effects

Shorter-lasting effects

Withdrawal Symptoms

Not used to reverse opioid overdose

Can precipitate opioid withdrawal symptoms

Abuse Potential

Not associated with abuse or euphoria

Not typically abused for euphoria, used solely for emergency situations

Overdose Reversal

Not used for opioid overdose reversal

Rapidly reverses opioid overdose effects

Treatment Setting

Can be prescribed for outpatient use

Administered by medical professionals in emergencies

Safety Precautions

Caution in patients with liver or kidney issues

Requires proper training for administration to prevent misuse


Available with prescription

Available with prescription and as a (Narcan, Evzio)

What to Avoid When Taking Low Dose Naltrexone?

Overdosing can be a fatal risk while taking low dose naltrexone. Credits: ReviewsFellas©
  1. Avoid Opioids and Alcohol: If you're considering LDN, it's crucial to avoid opioids and alcohol. Combining LDN with these substances can lead to adverse reactions and interfere with the treatment's effectiveness.
  2. Dosage Timing: Maintaining naltrexone dosage is crucial for individuals.
  3. Do not use Self Medication: LDN and standard naltrexone have different uses. LDN modulates the immune system, while standard naltrexone is used for addiction treatment.
  4. Careful about overdosing: It's important to be mindful of the amount of medication you're taking to avoid any accidental overdoses. Remember to stick to your prescribed medication and dosage schedule!
  5. Consult with a Medical Expert: Consult with an expert before starting LDN to ensure its appropriateness for your condition and receive personalized usage guidance.


Naltrexone in low doses, also known as LDN, is a medication that has potential uses beyond its typical application for addiction treatment. Its distinctive impact on the immune system and endorphins makes it an option for various medical conditions.

Now you know everything about what to avoid when taking low dose naltrexone. To determine if LDN is suitable for you, it's important to avoid certain substances, such as opioids and alcohol, follow the correct dosage, and maintain open communication with your physician.

Frequently Asked Questions (FAQs)

Q: What are the side effects of Low Dose Naltrexone?

Ans: LDN is generally safe to use, but it may cause some mild side effects such as insomnia, gastrointestinal discomfort, and vivid dreams.

Q: How much does low-dose naltrexone cost?

Ans: A low-dose naltrexone (LDN) prescription costs between $30 and $100 per month in the US without insurance.

Q: How long crystal meth stay in your system?

Ans: Crystal meth's effects can remain for 2 to 4 days, although it can be found in specific tests for up to 7 days following consumption.

Q: How long opioids stay in your system, and how long does it typically take to eliminate them?

Ans: It takes approximately 3-5 days for opioids to exit your body, but they may remain detectable in your system for up to 1-3 days.

Q: Does naltrexone help against trazodone and alcohol?

Ans: Naltrexone treats alcohol and opioid dependence, while trazodone is an antidepressant.

Q: How long does naltrexone effect last?

Ans: Specific formulations and dosages of naltrexone may have different effects. An average naltrexone tablet lasts between 24 and 48 hours.