This article is reviewed, corrected, and approved by: Dr. Joshua Collins M.D. | MRCP। FRCP

Lamotrigine is a medication that doctors often prescribe to treat different neurological conditions. It falls under the category of anticonvulsants, which are used mainly for managing seizures.

The mechanism of action of this drug involves stabilizing abnormal electrical activity in the brain, which in turn prevents or reduces the occurrence of seizures. There is some food that may interact with food. We will see what kind of food you need to avoid when you are taking a lamotrigine supplement.

What Is Lamotrigine & How Does It Work To Treat Seizures?

Lamotrigine is used as an epileptic drug. A man showing purple ribbon as a sign of epilepsy. Credits: ReviewsFellas©

It is an anti-epileptic drug (AED) used to treat seizures and treat bipolar disorder. Bipolar disorder symptoms such as seizures and mood swings are prevented by lamotrigine by stabilizing abnormal electrical activity in the brain. Here are some


  1. Lamotrigine is often used to treat various types of seizures. For example
  2. Generalized seizures (such as tonic-clonic seizures)
  3. Absence seizures, and
  4. Partial-onset seizures

B. It helps reduce the frequency and severity of seizures by modulating the release of certain neurotransmitters and inhibiting the excessive firing of neurons.

C. The truth about lamotrigine is, it's an anticonvulsant medication primarily used for the treatment of epilepsy. It is also prescribed for bipolar disorder as a mood stabilizer.

Bipolar Disorder

  1. Lamotrigine is also approved for the maintenance treatment of bipolar disorder, specifically for the prevention of depressive episodes in individuals aged 18 years and older.
  2. Neurotransmitters like glutamate and GABA regulate mood by stabilizing brain chemicals.

Off-label Uses

  1. Lamotrigine, apart from its approved uses, can also be prescribed off-label for conditions such as neuropathic pain, PTSD, and borderline personality disorder.
  2. Off-label use should always be discussed and monitored by a healthcare professional.

How Can Your Eating Habits Influence the Effects of Lamotrigine?

When taking Lamotrigine, it is important to consider the impact of your diet on the medication's effectiveness and potential side effects. Certain foods can interact with Lamotrigine, affecting its absorption, metabolism, and overall efficacy. Here are some reasons why dietary considerations are crucial when taking Lamotrigine:

  • Optimal Absorption: Taking Lamotrigine as advised by your healthcare provider with or without food can help maintain consistent blood levels and maximize its effectiveness, as food can affect its absorption.
  • Avoiding Interactions: Food interactions can affect Lamotrigine's effectiveness and cause unexpected side effects. Be aware of these interactions to minimize risks and ensure the medication works properly.
  • Consistent Sodium Intake: Sodium levels can affect Lamotrigine effectiveness. Consistent sodium intake can optimize benefits.
  • Managing Side Effects: To ease any stomach discomfort when taking Lamotrigine, try eating easily digestible foods or taking the medication with a meal.
  • Alcohol and Caffeine Interactions: Alcohol and caffeine consumption can affect the metabolism and clearance of Lamotrigine from the body. Try to limit or avoid alcohol and caffeine intake to minimize potential interactions and ensure the medication's effectiveness.

How Food Can Affect the Absorption and Effectiveness of Lamotrigine?

The absorption and effectiveness of Lamotrigine, like many other medications, can be influenced by the presence of food in the digestive system. Understanding how food affects the absorption of Lamotrigine is important to ensure optimal treatment outcomes. Here's an overview of how food can impact the absorption and effectiveness of Lamotrigine:

  1. Absorption Delay: Taking/eating a high-fat meal while taking Lamotrigine can slow down its absorption, leading to slower effectiveness.
  2. Food Interaction Variability: Food can affect the absorption of Lamotrigine differently in each person. Consistently taking it with or without food, as recommended by a healthcare professional is crucial for stable blood levels.
  3. Individual Response: Metabolism, gastric emptying time, and other medications can affect how Lamotrigine is absorbed.

To optimal absorption and effectiveness of Lamotrigine, here are some general guidelines:

  • Follow the dosing instructions provided by your physician.
  • Take Lamotrigine consistently with or without food, as advised by your healthcare professional. If specific instructions are not provided, it is generally recommended to take Lamotrigine on an empty stomach or with a light meal to minimize the potential delay in absorption.
  • Avoid consuming high-fat meals when taking Lamotrigine, as they can significantly delay absorption.
  • Speak to your physician about adjusting Lamotrigine timing with changes in dosage or other medications.

4 Types of Foods to Avoid When Taking Lamotrigine

High-Fat Foods

An assortment of high-fat foods. Credits: ReviewsFellas©

High-fat meals can significantly impact the absorption of Lamotrigine. Here's an explanation of how high-fat foods can affect the absorption of Lamotrigine:

  • Delayed Absorption and reduced bioavailability: Eating high-fat meals can slow down the absorption of Lamotrigine, reducing its effectiveness and causing inconsistent blood levels.
  • Inconsistent Blood Levels: Taking Lamotrigine with high-fat meals can lead to fluctuations in the blood levels of the medication. This can make maintaining a consistent therapeutic effect challenging and raise the risk of seizures or mood problems.

Alcohol and Caffeine

Alcohol and Caffeine Interaction with Lamotrigine:

Alcohol Interaction: In combination with alcohol, lamotrigine has the potential to impact the central nervous system and thus exacerbate negative effects.

Here's how the interaction between Lamotrigine and alcohol can occur:

  • Increased Drowsiness and Dizziness: The central nervous system is sedated by both lamotrigine and alcohol. When taken together, they can intensify these effects, leading to increased drowsiness, dizziness, and impaired coordination.
  • Potential Cognitive Impairment: Lamotrigine alcohol can impair cognitive functions, such as attention, judgment, and decision-making. Performing mental tasks such as driving or operating machinery can be affected by this.
  • Increased Risk of Mood Swings: Liquor is known to disrupt the delicate balance of neurotransmitters in the brain, which can potentially interfere with the mood-stabilizing effects of lamotrigine. Avoid excessive consumption to maintain the therapeutic benefits of Lamotrigine for bipolar disorder.

B. Caffeine Interaction: Some individuals might experience interactions with Lamotrigine if they consume excessive caffeine. Moderate caffeine usage, on the other hand, has been viewed as harmless. This is how the interaction can occur:

  • Increased Excitability: Caffeine is a stimulant that can increase neuronal excitability and may counteract the calming effects of Lamotrigine. Some individuals may experience increased restlessness or irritability when combining high doses of caffeine with lamotrigine.
  • Interference with Sleep: Caffeine is known to interfere with sleep quality and can exacerbate sleep-related side effects of Lamotrigine, such as insomnia or disrupted sleep patterns. It is advisable to limit caffeine intake, particularly in the evening, to minimize sleep disturbances.

Sodium-Rich Foods

Influence of Sodium on Lamotrigine Levels in the Body: While there is limited direct evidence on the interaction between sodium and Lamotrigine, some studies suggest that high sodium intake may impact the effectiveness of Lamotrigine. Here's an overview of how sodium-rich foods can potentially influence Lamotrigine levels in the body:

  • Sodium and Water Balance: Sodium is an essential mineral involved in maintaining fluid balance in the body. High salt intake can cause fluid retention and alter the concentration of drugs in the bloodstream, including Lamotrigine.
  • Sodium's Impact on Kidney Function: Too much sodium can harm the kidneys and affect their ability to filter substances, including medications like Lamotrigine, which may impact its effectiveness.
  • Individual Variability: Sodium intake affects Lamotrigine levels differently for each person. Consulting with a healthcare professional can provide personalized guidance on sodium intake and its potential impact on Lamotrigine therapy.

Soy Products

Raw and dried soybeans. Credits: ReviewsFellas©
  • How Soy Affects Lamotrigine Absorption: While soy products have not been extensively studied for their specific interactions with Lamotrigine, there is evidence to suggest that soy may influence the absorption of certain medications. Here's an explanation of how soy can potentially affect Lamotrigine absorption:
  • Isoflavones in Soy: Soy products contain compounds called isoflavones, which are phytoestrogens. These isoflavones may interfere with the absorption of some medications, although the extent and significance of this interaction are not well-established for Lamotrigine.
  • Potential Decreased Absorption: Some studies suggest that isoflavones in soy can bind to proteins in the digestive system and reduce the absorption of certain drugs. While the impact on Lamotrigine absorption specifically is not well-defined, it is advisable to exercise caution and be mindful of potential interactions.

Pros and Cons Of Lamotrigine



Effective in treating various seizure disorders.

Rash and serious skin reactions are possible, especially in children and those with hypersensitivity to other antiepileptic medications.

As a treatment for bipolar disorder, it functions as a mood stabilizer.

It may increase depression or mood disorders to some individuals 

It May help prevent depressive episodes in bipolar disorder

Requires careful monitoring and dose adjustment to minimize side effects and achieve optimal therapeutic benefit

Well-tolerated and less sedating than some other antiepileptic drugs.

Can cause dizziness, drowsiness, and blurred vision, which may affect coordination and ability to perform tasks requiring mental alertness

Long-term use has shown effectiveness in reducing the frequency and severity of seizures.

Serious skin responses, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported, and these conditions can be life-threatening.

It could be used as add-on therapy in partial seizures.

Complications with other drugs, including contraceptive pills, may affect birth control activity. 

Lamotrigine For Anxiety & lamotrigine in pregnancy

This supplementation is safer to use during pregnancy and for reduce anxiety compared to some others. 

This treatment may be able to improve memory, learning, and other cognitive abilities.

Possible liver toxicity, with a small risk of hepatotoxicity, requires regular liver function monitoring.

It could be beneficial in managing neuropathic pain. 

It May cause hormonal imbalances, such as changes in menstrual patterns or decreased efficacy of hormonal contraceptives

Lower risk of weight gain compared to some other antiepileptic drugs.

In rare cases, it can lead to blood disorders, including agranulocytosis and aplastic anemia


To optimize Lamotrigine's effectiveness and minimize interactions, avoid high-fat foods, consume alcohol and caffeine in moderation, and seek personalized guidance from a physician or dietitian regarding sodium-rich foods and soy products.

Mindful eating can enhance the benefits of Lamotrigine. Consult with your healthcare professional for specific dietary advice. Managing your diet is essential for optimizing your well-being and ensuring safe treatment for your neurological condition.