This article is reviewed, corrected, and approved by: Julia Weiss CNP| RN | MPH

Antibiotics are powerful medications that can save lives, but they should only use when essential. Tiny organisms or microorganisms attack the human body. Antibiotics are used to kill those bacteria and infections, and these medicines can kill or stop their growth.

On the other hand, antibiotics are ineffective against viruses, which are another type of organism that can cause illness. Lots of antibiotics can be found; each one works in a different way.

Some antibiotics kill bacteria by destroying their cell walls, while others prevent them from reproducing or interfere with their ability to make proteins or DNA. So, I am about to discuss how you can benefit from antibiotics and what are the side effects of antibiotics you need to keep in mind.

What Problems Can Antibiotics Cause?

Tiredness and lethargy are one of the most prominent problems of antibiotics. Credits: ReviewsFellas©

As a consequence of taking antibiotics, numerous health issues can arise as side effects. Fatigue or tiredness is a common effect, alongside other adverse reactions that can occur from the use of antibiotics.

Disruption of Gut Microbiota

Antibiotics are designed to kill harmful bacteria, but they may also affect the balance of good bacteria in the intestine. This disruption can affect the production and absorption of certain nutrients and metabolites that play a role in energy regulation. Consequently, an imbalance in gut microbiota may contribute to feelings of tiredness.

Immune System Activation

Antibiotics can stimulate the immune system as they combat infections. The immune system response involves the release of various chemicals and cytokines, which can lead to feelings of lethargy.

Individual Variation

Each person's response to antibiotics can differ. Some people may suffer exhaustion or weakness as a side effect, whereas other individuals may not be impacted at all. The effects of medications can also be influenced by factors such as overall health and existing medical conditions.

Underlying Infection

Fatigue can also arise from the infection itself. Bacterial infections often trigger an immune response, which can result in feelings of tiredness. Antibiotics target the infection, but it may take time for the body to recover and regain energy levels fully.

Other Side Effects

It's worth noting that antibiotics can cause additional side effects that may indirectly contribute to fatigue. These can include gastrointestinal disturbances, such as nausea or diarrhea, which can affect nutrient absorption and overall well-being.

There are the most common issues caused by antibiotic side effects. The severity and duration of those side effects will vary.

Risk Factors of Taking Antibiotic

A man suffering from the pain of liver problems which is a risk factor for antibiotics. Credits: ReviewsFellas©
  • Allergic reactions: Some people are allergic to antibiotics, and taking them can cause a reaction, such as a rash, hives, or difficulty breathing (Asthma).
  • Kidney or liver problems: Antibiotics can be harmful to the kidneys or liver, so people with these conditions should be careful when taking them.
  • Clostridium Difficile Infection (CDI): CDI is a serious infection that can occur after taking antibiotics. This causes nausea, vomiting, and abdominal discomfort.
  • Intestinal flora: Antibiotics can kill healthy bacteria in the intestines, causing antibiotic constipation, yeast infections, diarrhea, and other issues.
  • Antibiotic resistance: When antibiotics are used excessively, bacteria can develop resistance, which can diminish the effectiveness of these drugs in treating infections in the future.
  • Drug interactions: If you take antibiotics with some other medication, it might be harmful to you. Some drugs like antidiabetics, heart disease medication, and immunosuppressants may highly interact with antibiotics.
  • Development of drug-resistant genes in bacteria: By using antibiotics, we can inadvertently encourage the growth of drug-resistant genes in bacteria, leading to the transfer of this resistance to future generations of bacteria.

How Do You Recover From Antibiotic Weakness?

A balanced diet can help you recover from antibiotic weakness. Credits: ReviewsFellas©

A question people often ask is, do antibiotics make you tired? The answer is it does. Getting tired is a common effect of antibiotics as they stimulate the immune system during infection, leading to the release of chemicals and cytokines that can cause fatigue.

  • Rest and prioritize sleep: Give some extra time for your body to recover by getting some rest by ensuring you're getting adequate sleep. Make a sleep schedule and create a sleep-friendly environment.
  • Stay hydrated: You need to drink liquid or fluid to stay hydrated. Proper hydration can help combat fatigue and support overall well-being.
  • Eat a balanced diet: Ensure that your nutritious diet includes a wide variety of vegetables, lean proteins, and tropical fruits or fruits that contain antioxidants. This will assist your body in recovering energy.
  • Consider probiotics: Including probiotics in your diet or taking a probiotic supplements can help restore gut health by counteracting the impact of antibiotics. Consult your healthcare provider for recommendations.
  • Engage in light physical activity: Gentle exercises, such as walking or stretching, can boost circulation and energy levels. Start with low-impact activities and gradually increase intensity as you regain energy.
  • Manage stress levels: Use relaxation-promoting techniques such as deep breathing, meditation, or doing activities you enjoy to manage stress.
  • Discuss with your healthcare provider: If the fatigue persists or becomes concerning, it's important to consult with your healthcare provider. They can evaluate your overall health, assess if any underlying conditions contribute to fatigue. They can check your physical condition and guide you to what you need most.


Q: Does amoxicillin make you tired?

Ans: Amoxicillin is a popular antibiotic used to treat infections caused by bacteria. While fatigue is not a commonly reported amoxicillin adverse effect.

Q: Can antibiotics make you tired?

Ans: Yes, antibiotics can potentially make you feel tired as a side effect.

Q: Do antibiotics cause constipation?

Ans: It is true that certain antibiotics can cause constipation. As a result of antibiotic use. The gut's beneficial bacterial equilibrium can be affected.  which can negatively impact digestion.

Q: Can antibiotics cause heart palpitations?

Ans: The effects of antibiotics on the heart are uncommon. Some antibiotics have been linked to the possibility of heart palpitations.

Q: How long do antibiotics stay in your system?

Ans: There are many factors that determine how long antibiotics stay in your system, including the individual antibiotic, dosage, and duration. Also, individual factors such as the metabolism and immune system are related.

Q: Does over the counter antibiotics are available?

Ans: No oral otc antibiotics are not founded in the US. However, some topical OTC antibiotics can be purchased without a prescription. For example, Polymyxin B, Bacitracin, and Neomycin


Finally, antibiotics shouldn’t be taken without being prescribed by your doctor. This will assist in guaranteeing that the virus is totally eradicated and that the bacteria do not become resistant to the antibiotic. Taking antibiotics too long can increase the chances of developing antibiotic resistance.

It happens when bacteria evolve and become resistant to antibiotics' effects. Consequently, they will be less effective in treating future infections. So, it is best for you to stop taking them after consulting your physician. Use antibiotics when it is compulsory to combat bacterial infection.