As the medical community continues to debate HIV and its correlation to autoimmune diseases, experts have yet to find a definitive answer as to whether or not HIV is indeed an autoimmune disease.

This article examines both sides of the argument and dives into what exactly an autoimmune disease is, how it differs from HIV, and why it's important to know what makes them different. We'll also explore HIV infection, symptoms, types of HIV, and treatments available for both.

What is HIV?

HIV (Human Immunodeficiency Virus) attacks CD4 cells (also called T cells), which are essential for fighting other infections too. HIV can be transmitted by blood, semen, vaginal fluid, breast milk, and other body fluids. If left untreated, it can cause AIDS (acquired immunodeficiency syndrome).

Despite HIV's inability to be cured, antiretroviral therapy can suppress the virus and help people living with HIV maintain good health. Certain Autoimmune diseases may be caused by both genes and the environment. In addition to treating symptoms and slowing the progression of autoimmune diseases, there is no cure for this disease.

HIV Infection

There is much debate surrounding whether or not HIV is autoimmune or not. Some experts believe that, while others contend that it is not. The main argument against HIV is classified as an autoimmune disease, is that the virus does not attack the body or a person's immune system or healthy cells but rather targets cells that are already infected.

However, there are some similarities between HIV and other autoimmune diseases, such as the fact that both involve the body's immune system attacking itself. Moreover, some people with HIV do develop autoantibodies, which are proteins that mistakenly attack healthy cells.

Where did AIDS (HIV) originate?

HIV's origins and how it infected humans are still a subject of debate. Some scientists believe that HIV originated in primates in Africa and was then transferred to humans through contact with infected blood or tissues. Others believe that HIV may have originated in Europe or the Americas and then spread to Africa through infected individuals.

It is difficult to determine the exact origins of HIV because the virus has been present in human populations for a long time and has had time to mutate and evolve. However, studying the genetic history of HIV can give us some clues about where it came from. For example, one study found that the strains of HIV that are most common in Africa are more closely related to a strain of simian immunodeficiency virus (SIV) that infects chimpanzees than they are to other strains of SIV found in other parts of the world.

This suggests that HIV may have originated in Africa after transferring from chimps to humans. Further research is needed to determine the true origins of HIV, but understanding where the virus came from is important for developing effective treatments and prevention strategies.

Types of HIV

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Type-1 HIV

A majority of acute HIV infections worldwide are caused by HIV-1. It is the most common type of HIV. It is more virulent than HIV-2, progressing faster and often leading to AIDS. If untreated, it can be fatal.

Type-2 or Stage-2 HIV

HIV-2 is less common, with most cases occurring in West Africa. It is less virulent and progresses more slowly than HIV-1. It is also much less likely to lead to AIDS if left untreated. Keep remembering other variants of HIV, such as HIV-3(AIDS), have been identified but are not yet well understood.

Stage 3 (AIDS)

Stage 3 is known as acquired immunodeficiency syndrome (AIDS). In this stage, the virus has done a lot of damage to the person's immune system, making them more likely to get infections and cancers.

What is Autoimmune Disease?

Celiac Disease is an autoimmune disease. Credit- ReviewsFellas© 

Autoimmunity, where the immune system mistakenly attacks healthy cells, tissues, and organs, is a leading cause of several disorders. The immune system is responsible for warding off harmful invaders like viruses and bacteria.

During autoimmune diseases, however, the immune system is unable to distinguish between healthy cells and harmful invaders, resulting in inflammation and damage to healthy cells.

Examples of Autoimmune Diseases:

  • Type 1 diabetes
  • Psoriasis
  • Rheumatic diseases (rheumatoid arthritis)
  • Graves' disease
  • Myasthenia gravis
  • Vitiligo
  • Systemic lupus erythematosus
  • Sjogren's syndrome
  • Crohn's disease
  • Hashimoto's thyroiditis
  • Ankylosing spondylitis
  • Celiac disease.
  • Eczema

The majority of autoimmune disorders are known as autoimmune and systemic diseases. There are chronic conditions that need long-term medical care, although there are treatments that can alleviate symptoms.

However, some evidence suggests that HIV infection can trigger autoimmune responses in the body, although HIV is not an autoimmune disease.

A number of HIV-positive individuals have been found to have autoimmune disorders, such as autoimmune hemolytic anemia or AIHA and autoimmune thrombocytopenia (in which platelets in the blood are attacked and destroyed).

HIV infections can also cause chronic inflammation, which may subsequently contribute to the development of autoimmune diseases.

Some medications used for treating HIV, such as antiretroviral therapy, may also cause autoimmune-like reactions in some people. It has been shown that antiretroviral medications can cause drug-induced lupus, a condition caused by healthy tissues in the body being attacked by the immune system.

While HIV and AIDS are not autoimmune diseases, there is a clear relationship between the presence of HIV in a patient and the immune activation of his or her immune system. In order to fully understand this relationship and its implications for HIV and autoimmune diseases, more research is needed.

How Do Autoimmune Diseases Differ from HIV?

Autoimmune diseases and HIV (Human Immunodeficiency Virus) are two very different autoimmune conditions that affect the body in different ways.

Conditions known as autoimmune disorders occur when the healthy immune system mistakenly targets healthy cells, resulting in persistent inflammation and tissue damage.

HIV, on the other hand, CD4 cells (also known as T cells) are the cells of the immune system that are targeted by this virus. While autoimmune diseases and HIV are different conditions, they can both have a significant impact on a person's health and quality of life.

However, the underlying causes, symptoms, and treatments for these conditions are different, and it is important to seek medical care for a proper diagnosis and treatment plan.

Here are some differences between Autoimmune Diseases and HIV

Autoimmune Diseases



A system that protects the body from pathogens but may destroy healthy cells and tissues.

A system that protects the body from pathogens but may destroy healthy cells and tissues.


Genetic and Environmental factors.

Affected body fluids include blood, semen, vaginal fluids, and breast milk.


Fatigue, joint pain, skin rashes, and inflammation of various organs.

Flu-like symptoms.


Specific autoantibodies and blood test.

HIV diagnosis (CVS HIV test) is tested by blood or saliva for viral antibodies.


Corticosteroids, Nonsteroidal anti-inflammatory drugs (NSAIDs), and Disease-modifying antirheumatic drugs (DMARDs).

Highly active antiretroviral therapy (HAART), and living a healthy life.

How Does HIV Affect The Immune System?

The HIV virus damages the immune system, particularly CD4 cells (T cells), which are responsible for fighting infections. The HIV virus attaches to CD4 cells and produces copies of itself. Viruses kill CD4 cells and impair the immune system.

HIV viral infection can lead to AIDS, the most advanced stage. In the presence of a CD4 cell count below 200 cells per cubic millimeter, AIDS severely damages the immune system. AIDS patients are in danger of life-threatening opportunistic infections and malignancies.

Although not everyone who contracts HIV develops AIDS, the virus nonetheless weakens their immune system. Those who are HIV + but receive adequate medical care should expect to enjoy long, healthy lives. Important in HIV treatment, antiretroviral therapy (ART) is a combination of medications that suppress the virus and stop its growth, allowing HIV patients to keep their immune systems healthy.

How does HIV Get Spread?

A person with blue gloves holding a needle full of narcotics. Credit- ReviewsFellas© 

It is possible for HIV to spread through bodily fluids such as blood, sperm, genital secretions, and breast milk. Common modes of transmission include:

Unprotected Sexual Contact

A person who has had sexual contact with an HIV-positive individual may transmit the virus through any form of sexual contact. Condoms and PrEP medications (Pre-Exposure Prophylaxis) can be used to prevent infection.

Sharing Injection Equipment or Needles

There are several ways in which HIV can be transmitted from one individual to another. One of the following is sharing of injection equipment such as needles and syringes.

Mother-to-Child Transmission

HIV could be passed from mother to kid through breast milk or when the mother is pregnant. With timely medical help, the increased risk of passing the virus from the mother to the infant could be minimized.

Blood Transfusions and Organ Transplants

HIV can be transmitted through blood transfusions or organ transplants from a person who is infected with HIV. However, this is very rare in countries with an effective screening of blood and organ donations.

Simple gestures such as hugs, handshakes, or sharing cookware do not transmit HIV. Also, it cannot be transmitted through air, water, or insects that fly. If HIV-positive individuals receive the appropriate medical care and treatment, they may live a long and healthy life.

Symptoms of HIV Infection

According to the stage of the infection, HIV (Human Immunodeficiency Virus) symptoms can vary. Symptoms of HIV infection may not present themselves until years after infection. But, in rare cases, flu-like symptoms may appear a few weeks after infection. These symptoms may include:

  • Having a fever
  • Experiencing fatigue
  • Rashes
  • Symptoms of headache
  • Throat infection
  • Lymph nodes swollen

It is possible to experience these symptoms for a few weeks, and then they go away, and they may be mistaken for other viral infections.

After the initial infection, the virus can continue to multiply in the body without causing any symptoms for many years without causing symptoms.

People with HIV may experience other symptoms as the virus continues to attack their weakened immune system, including:

  • Continuous temperature elevation
  • Excessive sweating during the night
  • Frequent loose bowels
  • Loss of weight quickly
  • Fungal infections, such as oral thrush
  • Diseases or abnormalities of the skin
  • Tiredness
  • Swelling of the lymph nodes
  • Persistent infections

A person with these symptoms does not necessarily have HIV, and they can also be caused by other conditions. HIV can be detected only by testing, so it is important to get tested. A timely diagnosis and proper treatment of HIV can greatly improve quality of life and health outcomes.


HIV is not an autoimmune disease. It spreads viruses from person to person. Since the early 1980s, HIV has been a major global health issue. We have already discussed the reasons why it occurs. There is no known cure for HIV, which progresses slowly.

Treatments are available that may help slow the progression of the disease and prevent serious complications. You need to test for HIV immediately if you suspect viral exposure.

Frequently asked questions (FAQs)

Q: What does HIV stand for?

Ans: An abbreviation for HIV is human immunodeficiency virus (HIV)

Q: What is the meaning of HIV non-reactive?

Ans: A non-reactive HIV test result indicates no HIV antibodies or antigens were detected in a blood sample.

Q: What are HIV and AIDS?

Ans: HIV is the name of the virus that leads to AIDS. With early detection and treatment in many cases, HIV can be managed and AIDS prevented.

Q: Is shingles the first sign of HIV?

Ans: Shingles in HIV-positive patients are not a symptom of HIV infection.